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It remains unknown why this aggregation occurs

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149 Under specific conditions, ROS can bypass these pathways to induce pyroptosis, driven by inflammasome activation (e.g., NLRP3) in response to PAMPs/DAMPs, the predominance of inflammatory caspases (caspase-1/4/5/11) over caspase-8 or RIPK3, and cell-specific mechanisms prioritizing cytokine release (IL-1/IL-18) in immune cells like macrophages

Oxidative stress occurs when the organism is subjected to a variety of internal and external environmental stimuli and there is an imbalance between oxidative and antioxidant processes