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Free Radical Biology and Medicine, 47(2), 184-188

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329 The evidence linking myeloid cell fate and the NAD-NAMPT axis suggests an important mechanism for reprogramming myeloid cells through NAMPT (either extracellular or intracellular) inhibition

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However, the NAC monotherapy arm (600 mg three times daily) showed a trend toward slower decline in forced vital capacity (FVC) that did not reach statistical significance compared to placebo (Martinez et al., N Engl J Med, 2014) [45]