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Weber CR, Raleigh DR, Su L, Shen L, Sullivan EA, Wang Y, Turner JR

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At higher doses, some concern exists about pro-inflammatory effects: LL-37 can activate NF-kB pathways, potentially worsening certain inflammatory conditions

Finally, apremilast also decreases the systemic inflammatory status of patients with psoriasis, decreasing TNF-, IFN-, IL-12, and IL-23 production (17)