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The synthesis of these -glutamyl peptides by -GCS and GS appears more likely to occur when cells are under pathological conditions that feature a Cys deficiency (Figure 7)

Cisplatin is a platinum-based chemotherapy drug that was approved by the FDA in 1978 despite its harsh side effects of inducing organ damage (including the liver and kidneys) [299], through oxidative metabolism via CYP2E1 and CYP4A11 [300]

Phosphorylation of the C terminus of Fos protein is required for transcriptional transrepression of the c-fos promoter

The induction of ferroptosis by impairing STAT3/Nrf2/GPx4 signaling enhances the sensitivity of osteosarcoma cells to cisplatin

[DOI] [PubMed] [Google Scholar] 35.Drabkin DL