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The accumulation of ROS leads to the opening of the mitochondrial permeability transition pore (mPTP) and dissipation of the mitochondrial membrane potential, resulting in a surge of ROS in a phenomenon termed ROS-induced ROS release (RIRR) [46]

Acknowledgements The authors are thankful to the Nursing team and supporting staff at the Bangalore Medical College and Research Institute and to the volunteers for their participation in the study

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Indeed, NAC is a GSH precursor

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