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Description
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Emerging pathways including the Von Hippel-Lindau (VHL)-Hypoxia-Inducible Factor (HIF) axis, PR Domain Zinc Finger Protein 16 (PRDM16)/Uncoupling Protein 1 (UCP1) inhibition, Signal Transducer and Activator of Transcription 3 (STAT3)-driven FABP4 upregulation, and Yes-Associated Protein (YAP)/Transcriptional Co-Activator with PDZ-Binding Motif (TAZ) signalling, further highlight obesitys role in oncogenesis

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The patient is counselled regarding contraception, and that the patient is capable of complying with the need to use effective contraception (for further details refer to Contraception as follows), without interruption during the entire duration of treatment with Divalproex sodium/Valproate sodium
