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University of Minnesota, 2012

Sparks, J

Oxidative stress-mediated alterations in histone post-translational modifications

Senescent cells contribute to chronic inflammation via the senescence-associated secretory phenotype (SASP), the collective term for the pro-inflammatory chemokines and cytokines released by senescent cells Anyhow the DRI in FOXO4-DRI is short for D-retro-inverso: Retro-inverso peptides are linear peptides whose amino acid sequence is reversed and the -center chirality of the amino acid subunits is inverted as well

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Reader proteins, through their specific structural domains, recognize and bind to particular post-translational modifications on histones, interpreting these chemical marks as biological signals that regulate gene expression [265, 266]