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Receptor Activator of Nuclear Factor-B Ligand (RANKL) inhibitors, SOST inhibitors, and cathepsin K inhibitors are not included within the three major classes as targeted anti-OP agents (Table1)

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Therefore, we consider an ion combination approach by using the combination of Zn 2+ and Cu 2+ released from Zn/Cu dual-doped MSN to obtain a better DHT inhibition effect

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Loeber JG, Platis D, Zetterstrom RH, Almashanu S, Boemer F, Bonham JR, et al