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While the concept is in line with improving the key pathobiological defect in neurodegeneration (locus coeruleus degeneration, reduced noradrenergic innervation and decreased L-lactate production), further developments are needed to bring the proposal to a feasible clinical outcome

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Cells were seeded in complete medium consisting of RPMI-1640 supplemented with 10% FCS (Sigma), 1% Penicillin/Streptomycin (GIBCO), 1% L-Glutamine (Sigma), and 55 mM -mercaptoethanol (GIBCO)

Moreover, the bioactivity of phenolic compounds in vivo greatly depends on their metabolism (Figure 12), but phenol-conjugated metabolites have frequently shown a much lower radical scavenging capacity than the parent compounds and, unless some intracellular conjugation occurs, they are quite inactive as antioxidants [85]

Effects of exercise training on exercise capacity in patients with non-small cell lung cancer receiving targeted therapy