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Physiological concentrations of H 2 S also increased levels of the second messenger, cAMP, in primary cultures of brain cells, neuronal and glial cell lines, and Xenopus oocytes and activated the NMDA receptor in a protein kinase A (PKA)-dependent manner (Kimura, 2 S modulates several neuroprotective pathways, and modulation of its production may be beneficial

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121 Treatment of mice with a combination of rifampicin and isoniazid caused ROS formation and LPO in hepatocytes, a reduction of GPx4, and an increase in acyl-CoA synthetase long-chain family member 4 (ACSL4)

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