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96 Of note, GTPSCS functions as a lactyl-CoA synthetase in the nucleus and interacts with p300 to form a histone lactyltransferase complex to synergistically modulate H3K18la in this process

Analyses of TIF from tumours with WT Gclc and with Gclc knocked out (KO) showed that intracellular GSH synthesis partially contributed to tGSH levels in the TIF but not serum (Extended Data Fig

Null mutations of this gene increase susceptibility to some cancers, likely mediated by an increased susceptibility to environmental toxins and carcinogens

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In dermatology, TXA is used in topical treatments, which work very differently despite containing the same ingredient

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