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[DOI] [PMC free article] [PubMed] [Google Scholar] 82.Bacci M., Leme R., Zing N., Murad N., Adami F., Hinnig P., Feder D., Chagas A., Fonseca F
C.HamachilaA.HangomaJ.MunkombweD
The significance of the metabolic inhibition of PHD activity relates to the altered metabolic profile of cancer cells and how this altered metabolism aids in the propagation of cancer cells, in part, through inhibition of HIF1 degradation
A low concentration of these folding modulators in the cell often results in protein folding failures
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