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SOD1-mutant mice exhibited mitochondrial ultrastructural pathologies in spinal cord and skeletal muscle tissues, manifesting as reduced mitochondrial length, cristae disorganization, and increased spherical fragmented mitochondria (Mendez-Lopez et al., 2021)

Live labeling of synaptotagmin 1 and EGF receptors For the surface antibody stripping experiments of with Syt1 and EGF, neurons were incubated with 1:100 monoclonal mouse antibodies directed against the lumenal domain of Syt1 conjugated to Atto647N (custom made, Synaptic Systems, Gttingen, Germany), or 1:100 epidermal growth factor (EGF), complexed to Alexa Fluor 647 (#E35351

All of these functions decline during menopause

1Bb) post-surgery and both animals were euthanized as a result

Such oxidative stress in the brain can induce reversible and irreversible post-translational modifications of proteins, deficits in lipid metabolism, and the accumulation of toxins