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2.3 Programmed cell death 2.3.1 Apoptosis Apoptosis is a critical process in which cells initiate their orderly death, regulated by specific genes

142 Microglia are the resident macrophages of the central nervous system

J Neuroimmunol 257:97101

Hence, the donor and acceptor ought to be in close vicinity

Cystinosin-LKG, the alternatively spliced isoform of cystinosin, has a broader localization that could be leveraged to reduce cystine accumulation, restore lysosomal function, and lower apoptosis rates in cystinotic proximal tubule cells [155]