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Rare de novo variants associated with autism implicate a large functional network of genes involved in formation and function of synapses

The pentameric structure of IgM that provides a high valency to the molecule, and the low affinity of IgM polyreactive natural antibodies, both favor agglutination (100-10,000 times more effective than IgG), which is considered as a paramount component of the IgM-mediated virus neutralization

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T4 replacement therapy for subclinical hypothyroidism with HT results in lipid profile improvement [46], with positive changes in the relationships between protective and proatherogenic fractions of serum lipids, as well as optimizing blood pressure [47]

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Pre-infusion products from LTR and STR have distinct immunometabolic profiles We used an integrative approach to interrogate the immunometabolic properties of pre-infusion CAR T cell products from both sub-groups (Fig