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Its synthesis occurs in two steps

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A study using immunofluorescent staining confirmed that ketamine treatment resulted in increased expression levels of glucose transporter 3 (GLUT3) and phosphorylated ERK1/2 (P-ERK1/2) in astrocytes, but not in neurons, within the prefrontal cortex and suggested that ketamine enhances glucose metabolism in the prefrontal cortex through the nuclear localization of P-ERK1/2 in astrocytes, which promotes the expression of GLUT3 (Ouyang et al., 2021)