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Furthermore, the treatment efficacy is diminished due to the occurrence of platinum resistance

In addition, Jing revealed that immunoglobulin G (IgG) stimulation of human and murine macrophages results in the production of numerous proinflammatory mediators, including IL-1, which is dependent on HIF-1 and mTOR signaling, leading to metabolic reprogramming and subsequently driving inflammation in AIDs, such as RA, SLE, SSs, Sjgrens syndrome (SS) and vasculitis (76)

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Using data from mass spectrometry and specific antibodies, Kouzarides et al

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