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Effect of Dose of Hypertonic Saline on Its Potential to Prevent Lung Tissue Damage in a Mouse Model of Hemorrhagic Shock

Supplemental Figure 8

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Expression of Mn SOD (SOD2) and Cu/Zn SOD (SOD1) Enzyme Proteins in Mesenteric Resistance Arteries: Mn SOD protein expression (expressed as a percent of -actin loading control) was significantly higher in mesenteric resistance arteries of rats fed HS + Protandim (69.4 4.2%

While higher doses (particularly 54 mg) showed some increase in gastrointestinal-related events, these remained mild to moderate in severity and did not result in treatment discontinuation

Prevalence of injury is also mirrored in professional sporting populations, with the diagnostic grouping of most common injury as skeletal muscle/tendon in nature, accounting for 45% of all diagnosed injuries (Brooks 2005)