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Loren Pickart discovered it in 1973 while studying why plasma from young blood accelerated tissue repair in older liver cells

J Am Coll Surg 241(2):107-116, 2025

for example, CuZnSOD was known as erythrocuprein (or hemocuprein, or cytocuprein) or as the veterinary anti-inflammatory drug "Orgotein"

For example, MnO 2 nanomaterials can be used also as siRNA loading system for targeted delivery and controlled release siRNA for more effective gene expression regulation, which therefore allowed tumor-related gene therapy (24, 25)

Kidney Int , In press (2017)

Reduction of only a few essential SH-SH bonds in a biologic reactant can remarkably change its molecular properties