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Notably, the administration of L-carnitine ameliorates these alterations, as evidenced by reduced MDA and protein carbonyl levels, increased TAC, and decreased TOS content

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Further suppression of aggregation by introducing four additional spatially distant mutations localized at the self-association interface confirmed the involvement of this interface in ApoE aggregation

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Reportedly, VEGF signaling increases VEGFR2 expression and phosphorylation, and stimulates proliferation in VEGF-stimulated C2C12 cells (Supplementary Figure S2), and this might potentially reduce the effects of lenvatinib and L-carnitine in C2C12 cells

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