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doi: 10.1002/pbc.21144 29 Faganel KotnikBGrabnarIBohanec GrabarPDolzanVJazbecJ

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5-Amino-1-methylquinolinium iodide is the lead first-in-class small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) an enzyme overexpressed in white adipose tissue of obese individuals where it consumes the methyl-donor pool and depletes tissue NAD

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JTW antagonizes central excitability by regulating the levels of various neurotransmitters and hormones associated with insomnia (Sun et al