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Measuring 24-hour urinary magnesium excretion after an intravenous magnesium load may be used if kidney and GI function are normal

For some, statistically defined reference limits are used, whereas for others "true" cutoffs" based on a known relationship between the B12 biomarker and low body stores, functional impairment, or clinical signs of deficiency, are applied

Pre-existing inborn errors of sulfur-amino-acid metabolism (e.g., homocystinuria) represent an absolute contraindication because parenteral methionine can exacerbate elevated homocysteine concentrations and associated thrombotic risk

Lin H-L, Ueng K-C, Wang H-L et al (2013) The impact of IGF-I gene polymorphisms on coronary artery disease susceptibility

[2] The vitamin can also be supplied on prescription and delivered via injection or other means