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[DOI] [Google Scholar] 61.Kennedy E.P

Small Sci

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Our results unravel a transcriptional response that is able to sense nutrient fluctuation

One difficulty in understanding the pharmacology of bivalent and multivalent ligands is discerning whether the effects are from a cooperative synergistic binding mode or due to the effect of increasing the pharmacophore concentration without synergy effects

Biguanides A double-blinded randomized controlled trial (RCT) assessing the efficacy of metformin in the prevention of PIPN showed that the development of grade two or more peripheral neuropathy (PN) was significantly lower in the metformin group compared to placebo ( p = 0.001)