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35 to 40 percent of older adults who do not take supplements have inadequate B6 intake, and older adults often have difficulty obtaining enough B12 from their diet

In summary, the consumption of EDs is associated with a risk of drug interactions due to the documented potential of the most relevant components of EDs (caffeine, to a lesser extent taurine, ginseng, and Ginkgo) to enter into various interactions, both pharmacokinetic and pharmacodynamic

Further, these investigational agents are targeting a range of pathological mechanisms including protein homeostasis and neuroinflammation

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Future research on creatine supplementation and kidney function would greatly benefit from standardized reporting of assay type and calibration method, which would enable more precise synthesis of evidence