glutathione production genes Different pathways of production. G-pathway involves two Comparative transcriptome and metabolome analysis

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b-h , Effect of Grpr stimulation on growth of Grpr pos and Grpr neg mouse and human melanoma cell lines ( b ) 1064, ( c ) 1181-Ct, ( d ) 501mel-Ct, ( e ) 1014-Ct, ( f ) 1181-Grpr, ( g ) 501mel-GRPR, and ( h ) 1014-Grpr

Ferroptosis is an iron-dependent regulated necrosis that is considered a byproduct of cellular metabolism because of its close association with oxygen, iron, and lipid metabolism (116), it is dependent on the metabolites reactive oxygen species (ROS), phospholipids containing polyunsaturated fatty acid chains (PUFA-PL), and the transition metal iron, and exhibits biochemical features of iron accumulation and unrestricted lipid peroxidation, as well as morphologic alterations such as loss of plasma membrane integrity, mitochondrial abnormalities, cytoplasmic swelling, and moderate chromatin condensation (117, 118)