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Adipose tissue-derived hormones, such as leptin and adiponectin, are important in modulating hepatic AMPK activity

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FDX1 is a small protein from the ferredoxin family and contains an Fe-S cluster ( 2+ and release Cu + into the mitochondrial matrix ( + can directly bind to Fe-S clusters, which in turn disrupt their synthesis and function ( Figure 3 ) ( Figure 3 4 Abnormal copper metabolism and liver disease The liver plays a central role in copper metabolism, including absorption, storage, transportation and excretion

PLoS One 8, e58004

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They also demonstrated that CBD had a protective effect against the peroxide-induced reduction of polyunsaturated fatty acids in the cell membrane, helping to protect membrane integrity