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In 2013, an article was published claiming the hypothesis that TMAO is a causative compound of atherosclerosis. The hypothesis intrigued many researchers because it pointed out the relationship between intestinal microbiota and atherosclerosis

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Sleep disturbance: Sleep disturbances are the physical withdrawal symptom that occurs when the body tries to recover from prolonged crystal meth use, as shown in research titled Methamphetamine and sleep impairments: neurobehavioral correlates and molecular mechanisms published in 2021 by Oxford Academic

Therefore, more recent research has shifted the focus to screening a drug that targets the lipotoxicity of individuals with fewer side effects to prevent and treat KOA [10, 11]