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Patients on other supplements Avoid excessive cumulative doses of B vitamins

The effects of melatonin on mitochondria may be mediated via MT1/2 receptors, resulting in decreased ROS generation, higher antioxidant capabilities, and therefore, in less neural apoptosis, activating nuclear factor erythroid 2-related factor 2, as shown in preclinical models (24,92,103,104)
typical samples sizes were 3-5 biological replicates

Johnson et al., 2018

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Acknowledgements The authors appreciate the Research Supporting Project (304.PKIMIA.6501261.N120) by Nippon Sheet Glass Foundation, Japan
