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The 5xFAD mouse line has five mutations: the Swedish (K670N/M671L), Florida (I716V), and London (V717I) mutations in APP, as well as the M146L and L286V mutations in PSEN1

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Den frste begrensningen er den bifasiske dose-respons-sammenhengen

The reconstitution and administration of injectable medicines in the UK must be performed by, or under the direct supervision of, a qualified healthcare professional, following the product's SmPC and in accordance with NHS and NPSA guidance on the safer use of injectable medicines