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doi: 10.1016/j.jsbmb.2020.105607CrossRefGoogle ScholarPubMed

In addition, the brain is a major site of cholesterol synthesis, with cholesterol itself unable to pass through the blood-brain barrier

The high molecular weight proteins of the mitochondrial matrix, which cannot move through the mPTP, also contribute to the increased colloidal osmotic pressure

General Management Issues An important adjunct to the therapy of HCV is to advise chronically affected persons of measures that might be helpful in reducing or even preventing further fibrosis progression, independent of treatment

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes