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Heterozygous carriers generally do well with dietary optimization and a low-dose methylfolate supplement

The fundamental mechanism of ferroptosis is that highly expressed polyunsaturated fatty acids (PUFAs) are catalyzed on the cell membrane in the presence of ferrous ions and lipoxygenase (LOX), resulting in lipid peroxidation [41]

Suboptimal sperm methylation in terms of quality and quantity (CpG island regions restricted to retained histones) has a negative impact on human embryo blastocyst development [9] Approximately 1015% of histones are retained, but these are not randomly located: they bind to the active part/coding area of DNA and so play an important role in embryonic development [6,9]

Santos, J.L

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Widely targeted metabolomics tools are suitable for addressing the aforementioned issues as they offer high throughput, high sensitivity, and high qualitative accuracy, and comprehensive databases are available (16)