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Under normal physiological conditions, goblet cells continually produce mucins, however, factors such as cytokines, toxins, microbes and microbial product can negative or positively regulate this process [23]

The serum sodium and tonicity can be high due to extra-renal water losses

First isolated in 1974 from the brains of sleeping rabbits, DSIP has since been studied for effects extending far beyond sleep

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Three patients developed low blood pressure, uncontrollable shaking, shivering, and body aches shortly after or during administration of a product from the same vial

The regulatory pathway for biomarker approval adds additional complexity and delay to clinical implementation (Nisenblat et al., 2016)