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An Italian Society of Endocrinology guideline
Administration of L-NAME abolished the effects of hydroxocobalamin on all hemodynamic parameters

Mizuno R, Hojo H, Takahashi M, Kashio S, Enya S, Nakao M, Konishi R, Yoda M, Harata A, Hamanishi J (2022) Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide- N -methyltransferase
For most healthy patients, yes
In the presence of atrial flutter or atrial fibrillation, a transient modest slowing of ventricular response may occur immediately following adenosine administration