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doi: 10.3389/fphar.2017.00656 297

Saintilnord WN, Fondufe-Mittendorf Y

However, persistent loss of PD-1 signaling has both beneficial and detrimental effects on CD8 + T-cell function and fate

P = 0.001) and an 8.5% reduction in mucopurulent sputum ( P = 0.041) ( ERS Clinical Practice Guidelines (2025): The European Respiratory Society updated its management guidelines, issuing a conditional recommendation for the use of mucoactive drugs like NAC in specific NCFB phenotypes, particularly those with high sputum production and frequent exacerbations ( 7.2 Consensus of the expert panel Ninety percent of experts came to a consensus that 600 mg of NAC, taken twice daily, may be beneficial for patients with NCF bronchiectasis, and emerging evidence on its role in reducing exacerbation supports the opinion of 70% experts that NAC improves lung functions in these patients

doi: 10.3389/fmolb.2022.1080140 Received 25 October 2022 Accepted 15 December 2022 Published 06 January 2023 Volume 9 - 2022 Edited by Alessandro Corti, University of Pisa, Italy Reviewed by Alfonso Pompella, University of Pisa, Italy Bengt Mannervik, Stockholm University, Sweden Updates Copyright 2023 Matoba, Dohi, Choi and Kano

Moraru, A