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Pentoxifylline (PTX) is a synthetic derivative of methylxanthine that was initially used for the management of peripheral vascular disease

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Evidence of inflammatory immune signaling in chronic fatigue syndrome: A pilot study of gene expression in peripheral blood

Barwick AL, Tessier JW, Janse de Jonge X, Ivers JR, Chuter VH (2016) Peripheral sensory neuropathy is associated with altered postocclusive reactive hyperemia in the diabetic foot

Future randomized controlled clinical trials should prioritize combined interventions integrating AX supplementation with structured exercise programs, given the consistent synergistic effects observed on mitochondrial function, lipid oxidation, and muscle performance