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2.1.4 Tofersen Tofersen, crafted by Biogen as an innovative antisense oligonucleotide therapy, has a specific indication for adults with ALS who have a mutation in the SOD1 gene

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Indeed, dysregulated ROS production and oxidative stress have been implicated in a host of cardiac diseases, including cardiac hypertrophy, heart failure (HF), cardiac ischemiareperfusion injury (IRI), and diabetic cardiomyopathy (discussed in greater detail in refs 3,4,5,6 )

Acknowledgments For funding support we acknowledge Steigerwald Arzneimittelwerk GmbH, Darmstadt, Germany

Beyond its established deleterious role in CRC, recent studies have expanded the scope of F

Escobar-Morreale HF, del Rey FE, Obregon MJ, de Escobar GM