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Prior proteomics studies also showed a decrease in proteins uromodulin (UROM), kininogen-1 (KNG1), basement membrane-specific heparan sulfate proteoglycan core protein (PGBM), and nidogen-1 (NID1) in the urine of IC/BPS patients relative to controls 21,22

But treatment options are fairly new

PMID 27737898

However, adherence to Medicare guidelines for B12 injections is key to securing coverage