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44 , 135 Acute uncontrolled systemic inflammation in severe COVID-19 induces sepsis and multiple organ failure, and can lead to an elevation of vitamin B 12 level due to higher levels of transcobalamins I and II, their receptors, and unsaturated B 12 binding capacity in the blood

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The persistence of commensals in various niches of the gut likely contributes to a hosts ability to resist pathogen colonization through competitive exclusion [55], and the enhanced citrate metabolism could be a good indication of microbe-microbe mutualism

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