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BiP/Grp78 expression levels are increased in the hippocampus and temporal cortex of AD, and several studies have reported the increased presence of phosphorylated PERK, IRE1, and eIF2 in AD neurons (82, 336, 337)

Recent studies have reported that silent information regulator 1 (SIRT1), a class III protein deacetylase, is crucial for the control of cellular survival 17

[19] Steiber A, Kerner J, Hoppel CL.Mol Aspects Med

A landmark triple-blinded, placebo-controlled trial published in 2014 evaluated 120 subjects with low-to-moderate cardiovascular risk

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