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Ethics declarations Ethics approval All procedure approved by the Animal Science Committee of Tongji University

It is technically simple, minimal surgical risk, and result in quick patient recovery

Carbohydrate-restricted Diet and Exercise Increase Brain-derived Neurotrophic Factor and Cognitive Function: A Randomized Crossover Trial

Eur J Paediatr Neurol 31:3845 Akgun-Unal N, Ozyildirim S, Unal O, Gulbahce-Mutlu E, Mogulkoc R, Baltaci AK (2023) The effects of resveratrol and melatonin on biochemical and molecular parameters in diabetic old female rat hearts

Free radical damage to DNA and other cellular structures then accelerates, hastening the senescence of cells