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Furthermore, activity of the BER pathway was significantly increased in sALS patients (Kisby et al., 1997

Proteasome inhibitor PS-341 inhibits NF-B activity and promotes tumor cell apoptosis in renal cell carcinoma cell lines[63]

For example, using structure-based design it might be possible to improve E2E1-I53-50A by optimizing the cleavage site between E2 and E1 and by shortening the linker between the E2E1 and I53-50A moieties, The E2E1-NP immunogens elicited an immediate and strong Ab response against the HVR1 on E2