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Investigating VPA toxicokinetics and concentration/effect relationships may help understanding how to improve VPA-poisoned patient management

Smith JD, Terpening CM, Schmidt SO, Gums JG

While median urinary iodine concentration is a population indicator of recent dietary iodine intake, multiple collections of 24-hour urinary iodine are preferable to estimate intake in individuals (10-12)

carried out a retrospective inception cohort study to determine whether Lcarnitine therapy resulted in better hepatic survival amongst patients who experienced acute, severe, symptomatic valproateinduced hepatotoxicity

This pathway is considered to be neuroprotective as it can provide pyruvate when glycolysis is inhibited [115117]
