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TcdB1 selectively binds to CSPG4 and FZDs, TcdB2 to CSPG4 and TFPI, TcdB3 to FZDs, and TcdB4 to TFPI [78,79]

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For example, at equimolar amounts of F-DPPC and DPPC, interdigitated F-DPPC-rich domains create a phase-segregated system [69,117]

The exceptions are short-chain (less than 6 carbon atoms) and medium-chain (6 to 12 carbons) fatty acids, SCFA and MCFA, respectively

Figure 2 2.4 Lipid metabolism in BBB penetration Lipid metabolism plays a fundamental role in maintaining the structural and functional integrity of the BBB, a highly selective barrier that regulates molecular exchange between the bloodstream and the CNS (Pifferi et al., 2021)