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Lipid peroxidation and iron metabolism: two corner stones in the homeostasis control of ferroptosis

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Precursors entering the gut are absorbed by the upper gastrointestinal tract during oral administration and are unavailable to the microbes in the large intestine

Disruptions of the TrxR1 system, although not substantially impacting either the cellular redox balance or GSH pools, disrupts embryonic patterning, Nrf2 regulation, and other signaling-dependent processes [49]
