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Hypoxia enhances HIF-1 which up-regulated TfR and DMT1 to increase iron uptake, which effects the sensitivity of cells to ferroptosis (Xiong et al

It is restoring balance to the systems driving inflammation in the first place

Practically, this means the ODT requires higher doses to achieve comparable effects, and individual responses will vary more than with injections
All authors acknowledge full responsibility for the analyses and interpretation of the report

doi: 10.3389/fmicb.2020.00685 80 YamamotoTKidaYSakamotoYKuwanoK
