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Although reprogramming has historically used viral vectors, recent advancements in microRNA technology has led to the development of alternative transcription factor delivery methods that have been reported to increase the conversion efficiency in vitro and in vivo from somatic cells into functional dopaminergic neurons and ameliorate motor symptoms in a model of PD

They also play a role in signaling metabolites, modulating cell signaling, and apoptosis

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doi:10.1016/s0168-8278(98)80311-5

(PubMed) Reeves MA, Hoffmann PR