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Future studies should examine doseresponse relationships with multiple doses (0.5, 1, 2, and 4 mg/kg), compare pretreatment versus postreperfusion protocols, and incorporate serial sampling at multiple timepoints (2, 6, 24, 48, and 72 h)

2022;1(1) Bloom HL, Colombo J

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Regulation of autophagy, mitochondrial dynamics, and cellular bioenergetics by 4-hydroxynonenal in primary neurons