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Similar to exenatide, rapamycin and nicotinamide riboside may encounter challenges in later clinical trials due to the lack of a fully characterized mechanism of action in targeting PD

Further work is needed to confirm these findings in human patients and determine how bariatric surgery alters gut bacterial bile acid metabolism
Specifically, targeting mitochondrial bioenergetics with PGC-1 agonists, mitochondrial-targeted antioxidants like MitoQ and SS-31, and modulators of mitochondrial biogenesis should yield effective therapies (Table 1)

If you are struggling with health problems, please contact your doctor or other healthcare provider such as a Naturopathic Doctor, Dietitian, or Mental Health Professional to see if they can offer appropriate guidance and care

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[DOI] [PMC free article] [PubMed] [Google Scholar] 166.Barnabas R
