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Other common locations include the back, thighs, buttocks, and occasionally the face

Recent scientific breakthroughs point to a shared underlying mechanism: profound, systemic oxidative stress and the dysregulation of the body's most critical defense molecule
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Elevated levels of GluR1 in the midbrain: a trigger for sensitization to drugs of abuse
doi:10.1016/j.pnpbp.2004.11.001