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Overall, we have shown that we can use in silico molecular modelling to generate a series of senolytic peptides targeted to the FOXO4-TP53 interaction

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2020 Oct;12(41):45753u201362

In order to expand the toolbox of protocols for one-pot PROTAC synthesis using building blocks with different functional groups, Krumbs group published a new library of cereblon-based PROTACs targeting BRD4 protein via amide formation after a one-pot synthesis photoinduced C(sp 2 )C(sp 3 ) coupling (yields ranging from 7 to 93%)

BPC 157 offers a sophisticated approach to promoting cellular recovery for soft tissue and gastrointestinal health

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